A New Gestational Diabetes Mellitus Model, Hyperglycemia-Induced Eye Malformation via Inhibiting Pax6 in Chick Embryo
نویسندگان
چکیده
1 Anti-stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China 2 Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510006, China 3 Division of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College, Jinan University, Guangzhou 510632, China 4 Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Technology, Guangzhou 510095, China
منابع مشابه
A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo.
Gestational diabetes mellitus (GDM) is one of the leading causes of fetal malformations. However, few models have been developed to study the underlying mechanisms of GDM-induced fetal eye malformation. In this study, a high concentration of glucose (0.2 mmol per egg) was injected into the air sac of chick embryos on embryo development day (EDD) 1 to develop a hyperglycemia model. Results showe...
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